Search on: FLICE PROTEIN 
Descriptors Found: 1
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Descriptor English:   Caspase 8 
Descriptor Spanish:   Caspasa 8 
Descriptor Portuguese:   Caspase 8 
Synonyms English:   CAP4 Protease
Caspase-8
FLICE Protein
MACH Protein
Mch5 Protease
Pro Caspase 8
Pro-Caspase-8
Procaspase 8
Procaspase-8  
Tree Number:   D08.811.277.656.262.500.126.550.800
D08.811.277.656.300.200.126.550.800
D12.644.360.024.285.037
D12.644.360.075.405.550.800
D12.644.360.075.421.037
D12.776.157.057.018.037
D12.776.476.024.320.025
D12.776.476.075.405.550.800
D12.776.476.075.421.037
Definition English:   A long pro-domain caspase that contains a death effector domain in its pro-domain region. Caspase 8 plays a role in APOPTOSIS by cleaving and activating EFFECTOR CASPASES. Activation of this enzyme can occur via the interaction of its N-terminal death effector domain with DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEINS
Entry Combination - descr/qualif English:   Caspase 8/antagonists & inhibitors use Caspase Inhibitors
Caspase 8/deficiency use Alstrom Syndrome
 
See Related English:   Autoimmune Lymphoproliferative Syndrome
 
History Note English:   2007(2000) 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Record Number:   52227 
Unique Identifier:   D053181 

Occurrence in VHL:
 

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DeCS